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Vera Fichtner (1) , Eugen Schwarz (1) and Olaf Haeusler (2)
(1) Meggle GmbH, 83512 Wasserburg, Germany
(2) Roquette Frères, 62080 Lestrem, France
Introduction
In literature, the use of a combination of lactose and starch in pharmaceutical tablets is very often described. For such formulations a lubrication is a requested and the various lubricants have a diverse influence on the tablet characteristics.
The different physical properties of co-processed vs. the physical blend are reported and also the influence of Mg-stearate.
In our study we focused on the influence of various lubricants on the ejection force, tablet hardness and disintegration time of a compound vs. the physical blend based on lactose and starch.
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