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E. Schwarz (1), V.Fichtner (1) and O. Häusler (2)
(AAPS 2001)
(1): Meggle GmbH, 83512 Wasserburg, Germany
(2): Roquette Frères
The study compares the powder and tablet direct compression characteristics of a spray-dried lactose-starch compound versus the physical blend of spray-dried lactose and native white corn starch.
The change in physical properties by co-spray drying is reported for excipients or a calcium-sorbitol compound.
The most important characteristics for direct compression are highlighted; these include compound stability, flowability, compaction behavior and disintegration as well as dissolution.
For further information contact pharma.business.unit@roquette.com
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