>> Comparaison of native starches as tablet disintegrant

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O. Häusler¹, Ch. Brockmann², H. Rein²

1 Roquette Frères, 62080- Lestrem, France
Email olaf.haeusler@roquette.com, Tel +33 (321) 63-3753
2 Rheinische Friedrich-Wilhelms-Universität Bonn, Germany Institute of Pharmacy

(Scientific poster - PBP 7th world Meeting / Malta - March 2010)

Introduction

Native starches are extensively used as a disintegrant in tablets. Their action passes via an immediate swelling when wetted with aqueous liquids. Starches are isolated from raw materials of different botanical origin and they have therefore different physicochemical properties such as particle size or humidity. These differences could modify their functionality as tablet filler and disintegrant. The new EP edition (2009) completes the range of pharmacopeial starches with pea starch, isolated from pea (Pisum sativum L.). Comparative trials between several starches could assist the excipient choice. Tests were done with a soluble (lactose) and a non soluble (phosphate) tablet binder system.

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