|
Drug solubility is a genuine challenge for pharmaceutical formulators. Hydroxypropyl Beta cyclodextrin solubilizing power opens up new perspectives for dosage forms.
Hydroxypropyl beta cyclodextrin (HPßCD) encapsulation technology is well known for its solubilizing power. It also has other benefits making HPßCD the centrepiece in an enabling technology for challenging pharmaceutical formulations.
For a long time, this HPßCD technology has been used exclusively by a selected few. During the past few years, the patent environment for HPßCD has become more favourable for new formulations and the use of this technology in pharmaceuticals is now free of any broad-use restrictions in most of the main markets.
The main properties of HPßCD are briefly presented and the effects of HPßCD on drugs are reviewed. The full potential formulation power of this technology is becoming apparent for drug solubility; it is applicable in dosage forms for all the main administration routes but is of particular interest for injectable products.
Reproduced courtesy of Pharma Magazine
Read full article on PDF file
|
